About
The main research interests of the Giamal
Luheshi Neuroimmunology Group are centered
on investigating the interactions between the
peripheral immune system and the brain during
infection and inflammation. In particular,
the lab is interested in the role of a family
of immune mediators, cytokines, in this process.
Cytokines are a heterogeneous group of polypeptides
which, in addition to their role in mediating
peripheral immune function, have been shown
to act in the brain to trigger diverse physiological
and pathophysiological responses to peripheral
and brain insults.
These molecules have also been associated with
acute and chronic neurological diseases such
as stroke, Alzheimer Disease, schizophrenia
and others.
Using integrated and multidisciplinary
approaches, the laboratory is studying the
mechanisms of
action of cytokines by investigating:
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